@article {1004,
	title = {Brain atrophy in relapsing-remitting multiple sclerosis: Fractional volumetric analysis of gray matter and white matter},
	journal = {RADIOLOGY},
	volume = {220},
	year = {2001},
	note = {UT: 000170616700008ScopusID: 0034866802doi: 10.1148/radiol.2203001776},
	month = {2001///},
	pages = {606 - 610},
	abstract = {PURPOSE: To determine the fractional brain tissue volume changesin the gray matter and white matter of patients with relapsing-
remitting multiple sclerosis (MS) and to correlate these 
measurements with clinical disability and total lesion load. 
MATERIALS AND METHODS: Thirty patients with relapsing-remitting 
MS and 25 healthy control subjects underwent magnetic resonance 
imaging. Fractional brain tissue volumes (tissue volume relative 
to total intracranial volume) were obtained from the total 
segmented gray matter and white matter in each group and were 
analyzed. RESULTS: The fractional volume of white matter versus 
that of gray matter was significantly lower (-6.4\%) in patients 
with MS (P <.0001) than in control subjects. Neither gray matter 
nor white matter fractional volume measurements correlated with 
clinical disability in the patients with MS. CONCLUSION: Loss of 
brain parenchymal volume in patients with relapsing-remitting MS 
is predominantly confined to white matter. Analysis of 
fractional brain tissue volumes provides additional information 
useful in characterizing MS and may have potential in evaluating 
treatment strategies.
},
	isbn = {0033-8419},
	author = {Yiyue Ge and Robert J Grossman and Jayaram K Udupa and James S Babb and L{\'a}szl{\'o} G{\'a}bor Ny{\'u}l and Dennis L Kolson}
}
@booklet {1076,
	title = {Brain Atrophy in Relapsing-Remitting Multiple Sclerosis: A Fractional Volumetric Analysis of Gray Matter and White Matter},
	year = {2000},
	month = {2000///},
	author = {Yiyue Ge and Robert J Grossman and Jayaram K Udupa and James S Babb and L{\'a}szl{\'o} G{\'a}bor Ny{\'u}l and Dennis L Kolson}
}
@booklet {1074,
	title = {Magnetization Transfer Ratio Histogram Analysis of Normal Appearing Gray Matter and White Matter in MS},
	year = {2000},
	month = {2000///},
	author = {Yiyue Ge and Robert J Grossman and Jayaram K Udupa and James S Babb and L{\'a}szl{\'o} G{\'a}bor Ny{\'u}l and Dennis L Kolson and Lois J Mannon and Joseph C McGowan}
}
@article {994,
	title = {Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter},
	journal = {RADIOLOGY},
	volume = {216},
	year = {2000},
	note = {UT: 000088430800008ScopusID: 0033894599},
	month = {2000///},
	pages = {351 - 355},
	abstract = {PURPOSE: To investigate and characterize the global distributionof magnetization transfer (MT) ratio values of normal-appearing 
white matter (NAWM) in patients with relapsing-remitting 
multiple sclerosis (MS) and test the hypothesis that the MT 
histogram for NAWM reflects disease progression. MATERIALS AND 
METHODS: Conventional and MT magnetic resonance (MR) images were 
obtained in 23 patients and 25 healthy volunteers. Clinical 
tests for comparison with the MT histogram parameters included 
the Extended Disability Status Scale and the ambulation index. 
Lesion load calculated with T2-weighted MR images and whole-
brain and white matter volumes were measured. RESULTS: The 
location of the MT histogram peak and the mean MT ratio for NAWM 
were significantly lower in patients with MS than in control 
subjects. In longitudinal studies, the histogram peak location 
and mean MT ratio shifted in the direction of normal values as 
the duration of disease increased. A mean of 26.5\% of the volume 
of new lesions identified on the later studies were demonstrated 
to have originated in NAWM corresponding to "lost" pixels on the 
histogram. CONCLUSION: MT histogram analysis of NAWM, including 
longitudinal analysis, may provide new prognostic information 
regarding lesion formation and increase understanding of the 
course of the disease.
},
	isbn = {0033-8419},
	author = {Isabelle Catalaa and Robert J Grossman and Dennis L Kolson and Jayaram K Udupa and L{\'a}szl{\'o} G{\'a}bor Ny{\'u}l and Lougang Wei and Xuan Zhang and Marcia Polansky and Lois J Mannon and Joseph C McGowan}
}
@booklet {1072,
	title = {Magnetization Transfer Histogram Analysis of Segmented Normal- Appearing White Matter in Multiple Sclerosis},
	year = {1999},
	month = {1999///},
	author = {Isabelle Catalaa and Robert J Grossman and Jayaram K Udupa and L{\'a}szl{\'o} G{\'a}bor Ny{\'u}l and Dennis L Kolson and Lougang Wei and Xuan Zhang and Marcia Polansky and Lois J Mannon and Joseph C McGowan}
}
@conference {1020,
	title = {Magnetization Transfer Histogram Analysis of Segmented Normal-Appearing White Matter in Multiple Sclerosis},
	booktitle = {International Society for Magnetic Resonance in Medicine: Seventh Scientific Meeting and Exhibition},
	year = {1999},
	month = {May 1999},
	pages = {957},
	address = {Berkeley},
	author = {Isabelle Catalaa and Robert J Grossman and Dennis L Kolson and L{\'a}szl{\'o} G{\'a}bor Ny{\'u}l and Lougang Wei and Jayaram K Udupa and Marcia Polansky and Joseph C McGowan},
	editor = {*[International Society fo *Medicine]}
}
