02265nas a2200253   4500008004100000020001400041245010900055210006900164260001200233300001400245490000800259520138100267100002201648700002401670700002201694700002201716700002801738700001701766700001601783700002101799700002001820700002301840856014801863       2000                        eng d  a0033-841900aMultiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter0 aMultiple sclerosis Magnetization transfer histogram analysis of   c2000///  a351 - 3550 v2163 aPURPOSE: To investigate and characterize the global distributionof magnetization transfer (MT) ratio values of normal-appearing 
white matter (NAWM) in patients with relapsing-remitting 
multiple sclerosis (MS) and test the hypothesis that the MT 
histogram for NAWM reflects disease progression. MATERIALS AND 
METHODS: Conventional and MT magnetic resonance (MR) images were 
obtained in 23 patients and 25 healthy volunteers. Clinical 
tests for comparison with the MT histogram parameters included 
the Extended Disability Status Scale and the ambulation index. 
Lesion load calculated with T2-weighted MR images and whole-
brain and white matter volumes were measured. RESULTS: The 
location of the MT histogram peak and the mean MT ratio for NAWM 
were significantly lower in patients with MS than in control 
subjects. In longitudinal studies, the histogram peak location 
and mean MT ratio shifted in the direction of normal values as 
the duration of disease increased. A mean of 26.5% of the volume 
of new lesions identified on the later studies were demonstrated 
to have originated in NAWM corresponding to "lost" pixels on the 
histogram. CONCLUSION: MT histogram analysis of NAWM, including 
longitudinal analysis, may provide new prognostic information 
regarding lesion formation and increase understanding of the 
course of the disease.
1 aCatalaa, Isabelle1 aGrossman, Robert, J1 aKolson, Dennis, L1 aUdupa, Jayaram, K1 aNyúl, László, Gábor1 aWei, Lougang1 aZhang, Xuan1 aPolansky, Marcia1 aMannon, Lois, J1 aMcGowan, Joseph, C  uhttps://www.inf.u-szeged.hu/publication/multiple-sclerosis-magnetization-transfer-histogram-analysis-of-segmented-normal-appearing-white-matter