01809nas a2200289 4500008004100000245008600041210006900127260007000196300001400266490000600280520081400286100001901100700001701119700002801136700002201164700002101186700002301207700002301230700001901253700002101272700002301293700001801316700002201334700001801356700001901374856012601393 2007 eng d00aAppearance-based Approach to Extract an Age-related Biomarker from Retinal Images0 aAppearancebased Approach to Extract an Agerelated Biomarker from aErlangenbFriedrich-Alexander University Erlangen-Nurembergc2007 a127 - 1310 v13 a
We present an appearance-based method that extracts a new age-related biomarker from retina images. The Principal Component Analysis is applied on intensity values of the illumination corrected green channel of fundus images. The algorithm does not use segmentation, is robust and shows a high range of reliability. It identified an age-related feature with a strong influence of the temporal parapapillary area and the optic nerve head. The feature correlates with chronological age of the participants and is significantly influenced by the appearance of cardiovascular risk factors such as smoking and hypertension, and thus it can be designated a biomarker. We extract and validate a medical parameter from retina images applying a purely data-driven approach without using any prior knowledge.
1 aBock, Rudriger1 aMeier, Jörg1 aNyúl, László, Gábor1 aWärntges, Simone1 aMichelson, Georg1 aHornegger, Joachim1 aHornegger, Joachim1 aMayr, Ernst, W1 aSchookin, Sergey1 aFeußner, Hubertus1 aNavab, Nassir1 aGulyaev, Yuri, V.1 aHöller, Kurt1 aGanzha, Victor uhttps://www.inf.u-szeged.hu/publication/appearance-based-approach-to-extract-an-age-related-biomarker-from-retinal-images