TY - CHAP T1 - Appearance-based Approach to Extract an Age-related Biomarker from Retinal Images T2 - 3rd Russian-Bavarian Conference on Bio-Medical Engineering, Proceedings Y1 - 2007 A1 - Rudriger Bock A1 - Jörg Meier A1 - László Gábor Nyúl A1 - Simone Wärntges A1 - Georg Michelson A1 - Joachim Hornegger ED - Joachim Hornegger ED - Ernst W Mayr ED - Sergey Schookin ED - Hubertus Feußner ED - Nassir Navab ED - Yuri V. Gulyaev ED - Kurt Höller ED - Victor Ganzha AB -

We present an appearance-based method that extracts a new age-related biomarker from retina images. The Principal Component Analysis is applied on intensity values of the illumination corrected green channel of fundus images. The algorithm does not use segmentation, is robust and shows a high range of reliability. It identified an age-related feature with a strong influence of the temporal parapapillary area and the optic nerve head. The feature correlates with chronological age of the participants and is significantly influenced by the appearance of cardiovascular risk factors such as smoking and hypertension, and thus it can be designated a biomarker. We extract and validate a medical parameter from retina images applying a purely data-driven approach without using any prior knowledge.

JF - 3rd Russian-Bavarian Conference on Bio-Medical Engineering, Proceedings PB - Friedrich-Alexander University Erlangen-Nuremberg CY - Erlangen VL - 1 ER -