%0 Journal Article %J RADIOLOGY %D 2001 %T Brain atrophy in relapsing-remitting multiple sclerosis: Fractional volumetric analysis of gray matter and white matter %A Yiyue Ge %A Robert J Grossman %A Jayaram K Udupa %A James S Babb %A László Gábor Nyúl %A Dennis L Kolson %X PURPOSE: To determine the fractional brain tissue volume changesin the gray matter and white matter of patients with relapsing- remitting multiple sclerosis (MS) and to correlate these measurements with clinical disability and total lesion load. MATERIALS AND METHODS: Thirty patients with relapsing-remitting MS and 25 healthy control subjects underwent magnetic resonance imaging. Fractional brain tissue volumes (tissue volume relative to total intracranial volume) were obtained from the total segmented gray matter and white matter in each group and were analyzed. RESULTS: The fractional volume of white matter versus that of gray matter was significantly lower (-6.4%) in patients with MS (P <.0001) than in control subjects. Neither gray matter nor white matter fractional volume measurements correlated with clinical disability in the patients with MS. CONCLUSION: Loss of brain parenchymal volume in patients with relapsing-remitting MS is predominantly confined to white matter. Analysis of fractional brain tissue volumes provides additional information useful in characterizing MS and may have potential in evaluating treatment strategies. %B RADIOLOGY %V 220 %P 606 - 610 %8 2001/// %@ 0033-8419 %G eng %N 3 %! RADIOLOGY %0 Generic %D 2000 %T Brain Atrophy in Relapsing-Remitting Multiple Sclerosis: A Fractional Volumetric Analysis of Gray Matter and White Matter %A Yiyue Ge %A Robert J Grossman %A Jayaram K Udupa %A James S Babb %A László Gábor Nyúl %A Dennis L Kolson %8 2000/// %G eng %0 Generic %D 2000 %T Magnetization Transfer Ratio Histogram Analysis of Normal Appearing Gray Matter and White Matter in MS %A Yiyue Ge %A Robert J Grossman %A Jayaram K Udupa %A James S Babb %A László Gábor Nyúl %A Dennis L Kolson %A Lois J Mannon %A Joseph C McGowan %8 2000/// %G eng %0 Journal Article %J RADIOLOGY %D 2000 %T Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter %A Isabelle Catalaa %A Robert J Grossman %A Dennis L Kolson %A Jayaram K Udupa %A László Gábor Nyúl %A Lougang Wei %A Xuan Zhang %A Marcia Polansky %A Lois J Mannon %A Joseph C McGowan %X PURPOSE: To investigate and characterize the global distributionof magnetization transfer (MT) ratio values of normal-appearing white matter (NAWM) in patients with relapsing-remitting multiple sclerosis (MS) and test the hypothesis that the MT histogram for NAWM reflects disease progression. MATERIALS AND METHODS: Conventional and MT magnetic resonance (MR) images were obtained in 23 patients and 25 healthy volunteers. Clinical tests for comparison with the MT histogram parameters included the Extended Disability Status Scale and the ambulation index. Lesion load calculated with T2-weighted MR images and whole- brain and white matter volumes were measured. RESULTS: The location of the MT histogram peak and the mean MT ratio for NAWM were significantly lower in patients with MS than in control subjects. In longitudinal studies, the histogram peak location and mean MT ratio shifted in the direction of normal values as the duration of disease increased. A mean of 26.5% of the volume of new lesions identified on the later studies were demonstrated to have originated in NAWM corresponding to "lost" pixels on the histogram. CONCLUSION: MT histogram analysis of NAWM, including longitudinal analysis, may provide new prognostic information regarding lesion formation and increase understanding of the course of the disease. %B RADIOLOGY %V 216 %P 351 - 355 %8 2000/// %@ 0033-8419 %G eng %N 2 %! RADIOLOGY %0 Generic %D 1999 %T Magnetization Transfer Histogram Analysis of Segmented Normal- Appearing White Matter in Multiple Sclerosis %A Isabelle Catalaa %A Robert J Grossman %A Jayaram K Udupa %A László Gábor Nyúl %A Dennis L Kolson %A Lougang Wei %A Xuan Zhang %A Marcia Polansky %A Lois J Mannon %A Joseph C McGowan %8 1999/// %G eng %0 Conference Paper %B International Society for Magnetic Resonance in Medicine: Seventh Scientific Meeting and Exhibition %D 1999 %T Magnetization Transfer Histogram Analysis of Segmented Normal-Appearing White Matter in Multiple Sclerosis %A Isabelle Catalaa %A Robert J Grossman %A Dennis L Kolson %A László Gábor Nyúl %A Lougang Wei %A Jayaram K Udupa %A Marcia Polansky %A Joseph C McGowan %E *[International Society fo *Medicine] %B International Society for Magnetic Resonance in Medicine: Seventh Scientific Meeting and Exhibition %C Berkeley %P 957 %8 May 1999 %G eng