%0 Journal Article %J RADIOLOGY %D 2001 %T Brain atrophy in relapsing-remitting multiple sclerosis: Fractional volumetric analysis of gray matter and white matter %A Yiyue Ge %A Robert J Grossman %A Jayaram K Udupa %A James S Babb %A László Gábor Nyúl %A Dennis L Kolson %X PURPOSE: To determine the fractional brain tissue volume changesin the gray matter and white matter of patients with relapsing- remitting multiple sclerosis (MS) and to correlate these measurements with clinical disability and total lesion load. MATERIALS AND METHODS: Thirty patients with relapsing-remitting MS and 25 healthy control subjects underwent magnetic resonance imaging. Fractional brain tissue volumes (tissue volume relative to total intracranial volume) were obtained from the total segmented gray matter and white matter in each group and were analyzed. RESULTS: The fractional volume of white matter versus that of gray matter was significantly lower (-6.4%) in patients with MS (P <.0001) than in control subjects. Neither gray matter nor white matter fractional volume measurements correlated with clinical disability in the patients with MS. CONCLUSION: Loss of brain parenchymal volume in patients with relapsing-remitting MS is predominantly confined to white matter. Analysis of fractional brain tissue volumes provides additional information useful in characterizing MS and may have potential in evaluating treatment strategies. %B RADIOLOGY %V 220 %P 606 - 610 %8 2001/// %@ 0033-8419 %G eng %N 3 %! RADIOLOGY %0 Generic %D 2000 %T Brain Atrophy in Relapsing-Remitting Multiple Sclerosis: A Fractional Volumetric Analysis of Gray Matter and White Matter %A Yiyue Ge %A Robert J Grossman %A Jayaram K Udupa %A James S Babb %A László Gábor Nyúl %A Dennis L Kolson %8 2000/// %G eng %0 Generic %D 2000 %T Magnetization Transfer Ratio Histogram Analysis of Normal Appearing Gray Matter and White Matter in MS %A Yiyue Ge %A Robert J Grossman %A Jayaram K Udupa %A James S Babb %A László Gábor Nyúl %A Dennis L Kolson %A Lois J Mannon %A Joseph C McGowan %8 2000/// %G eng %0 Conference Paper %B International Society for Magnetic Resonance in Medicine: Eight Scientific Meeting and Exhibition %D 2000 %T Tissue Characterization in Relapsing-remitting and Secondary-progressive MS via Magnetization Transfer Ratio %A Yiyue Ge %A Robert J Grossman %A Jayaram K Udupa %A James S Babb %A László Gábor Nyúl %A Joseph C McGowan %E %B International Society for Magnetic Resonance in Medicine: Eight Scientific Meeting and Exhibition %C Berkeley %P 1189 %8 Apr 2000 %G eng